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KMID : 0869620150320040299
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Journal of Korean Society of Hospital Pharmacists
2015 Volume.32 No. 4 p.299 ~ p.307
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Sohn Gee-Ho
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Abstract
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Polypharmacy (multiple drug use) is considered one of the major risk factors in drugdrug
interactions and is a common problem among the elderly patients. It can lead to noncompliance or even discontinuation of the therapy. The purpose of this study was to assess the clinical usefulness, the prevalence, and severity of drug-drug interaction induced ADR (adverse drug reaction) in a long-term care hospital. A retrospective, observational review of electronic medical records and pharmacist interviews with patients were performed. The dataset was analyzed for ADR causality, ADR severity, patient demographic profiles and ADR related characteristics. 324 patients were included (156 males, 168 females), if they were prescribed medication with potential drug-drug interactions, between 1 January 2014 and 31 December 2014 (12 months total). Most patients (80%) were above 65 years old. The patients had a total of 1,680 drugs (average 5.2 drugs per patient), and 932 potential drug-drug interactions (average 2.89 per patient). The most common clinicaly useful ADRs were 17 peptic ulcer and a myopathy. These ADRs were in patients over 65 years age.
This indicates the need for rigid ADR monitoring to ensure safety for long-term care patients.
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KEYWORD
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Drug-drug interaction, ADR(adverse drug reaction), Long-term care hospital
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